Search on: SUPPRESSOR OF CYTOKINE SIGNALING PROTEINS 
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Descriptor English:   Suppressor of Cytokine Signaling Proteins 
Descriptor Spanish:   Proteínas Supresoras de la Señalización de Citocinas 
Descriptor Portuguese:   Proteínas Supressoras da Sinalização de Citocina 
Synonyms English:   SOCS Proteins
Suppressors of Cytokine Signaling Proteins  
Tree Number:   D12.644.360.024.374
D12.776.157.057.249
D12.776.476.024.437
Definition English:   A family of structurally related proteins that are induced by CYTOKINES and negatively regulate cytokine-mediated SIGNAL TRANSDUCTION PATHWAYS. SOCS proteins contain a central SH2 DOMAIN and a C-terminal region of homology known as the SOCS box. 
History Note English:   2006 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
AI antagonists & inhibitors BI biosynthesis
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification DF deficiency
DE drug effects EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Record Number:   50800 
Unique Identifier:   D050826 

Occurrence in VHL:
 

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